Retin-A has been around for 40 years for dermatological use with extensive clinical trials. It has proven to significantly reduce fine lines, mottled pigmentation, and roughness within 12–24 weeks of consistent use. Retin A does require a prescription from your dermatologist. Retin-A is also not well tolerated by anyone with sensitive skin. Using it for fewer days and mixing it with your night cream can mitigate some of the issues.
The new kid on the block is Resveratrol, a polyphenolic compound found in grapes, berries, and red wine, which has garnered attention for its potential anti-aging benefits when applied topically. Recent studies suggest that resveratrol creams may offer superior skin rejuvenation effects compared to traditional topical antioxidants by neutralizing free radicals that contribute to skin aging. Its anti-inflammatory properties further enhance its appeal in skincare. When applied topically, resveratrol has been shown to:
- Improve skin elasticity and firmness.
- Enhance collagen production
- Reduce fine lines and wrinkles
- Protect against UV-induced damage
- Even out skin tone and texture
These effects are attributed to resveratrol’s ability to activate sirtuins, particularly SIRT1, which play a role in cellular longevity and repair mechanisms.
However, while Resveratrol has been proven to be more effective than other over-the-counter anti-aging products, it does not perform as well as Retin-A. By using both products, Resveratrol in the morning and Retin-A in the evening, you have the ultimate anti-aging routine!
Top Routine for Better Skin
A consistent and effective daily skincare routine is essential for women over 50 to maintain a radiant, healthy complexion. With age, skin loses elasticity and moisture, and cell turnover slows down, so targeting hydration, firmness, and protection is key.
Here is a recommended routine for better daily skin. However, we suggest that you consult your dermatologist before beginning the use of both Resveratrol and Retin-A to make sure it’s a good fit for you and your skin type.
Morning Routine (Protection & Hydration)
Begin with a gentle cleanser to remove impurities without stripping the skin. Follow with a hydrating toner to prepare the skin for moisture. Apply a serum rich in antioxidants—like vitamin C—to brighten and combat environmental damage. Next, use a moisturizer containing hyaluronic acid or peptides to plump and nourish the skin. Finish with a broad-spectrum sunscreen (SPF 30 or higher), even on cloudy days, to protect against UV damage that accelerates aging.
Gentle Cleanser
Purpose: Clean without stripping the skin barrier
Antioxidant Serum with Resveratrol
Purpose: Neutralizes free radicals, reduces inflammation, supports collagen
Moisturizer
Purpose: Seal hydration, prep skin for SPF
Broad-Spectrum Sunscreen (SPF 30 or higher)
Purpose: Protect against UV damage, especially when using Retin-A at night
Evening Routine (Repair & Renewal)
Cleanse thoroughly to remove makeup and pollutants. Exfoliate 2–3 times a week using a mild chemical exfoliant (like glycolic acid) to encourage cell renewal. Apply a retinol or retinoid serum to stimulate collagen production and improve texture—starting slowly to minimize irritation. Follow with a rich night cream that supports skin repair and locks in moisture.
Additionally, prioritize sleep, hydration, and a balanced diet, as internal health directly impacts skin appearance. Tailoring this routine to your skin type and needs will help maintain a youthful, glowing complexion.
Gentle Cleanser
(Same as the morning routine with similar products)
Tretinoin (Retin-A) – Prescription Only (0.025–0.05% Cream)
Purpose: Stimulate collagen, reduce wrinkles, and pigmentation
Tips:
- Apply only a pea-sized amount to dry skin.
- Avoid sensitive areas (corners of eyes, mouth, nostrils).
- Start 2–3 nights a week, then increase as tolerated.
Moisturizer (Barrier Support)
Purpose: Minimize irritation and dryness
Optional: Alternate Resveratrol Nights
If you can’t tolerate nightly tretinoin, use your resveratrol serum on off nights. It soothes skin and continues antioxidant repair.
Weekly Add-Ons
Gentle Exfoliant (1x/week)
Avoid harsh scrubs. Use polyhydroxy acids (PHAs) or low % lactic acid.
Try: The INKEY List PHA Toner or Paula’s Choice 8% AHA Gel
Hydrating Mask (1–2x/week)
Use on nights without tretinoin for extra nourishment.
Try: Dr. Jart+ Ceramidin Facial Barrier Mask or First Aid Beauty Ultra Repair Instant Oatmeal Mask
Pro Tips for Success
- Start slow: Introduce Retin-A first, then add resveratrol (or vice versa).
- Use the “sandwich” method for tretinoin if you’re dry: moisturizer → tretinoin → moisturizer.
- Avoid layering Retin-A and resveratrol together in the same session to reduce the risk of irritation.
- Be patient: Real results from this routine typically emerge after 8–12 weeks.
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