Calibrate: Can a Metabolic Reset Help You Lose Weight?

Two African American Women walking - Calibrate weight loss

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In the U.S., over 175 million adults are struggling with their weight and metabolic health. That alone is an eye-popping statistic. What’s really surprising is that there are a scarce 5,000 obesity-certified doctors nationwide. That means that for every one obesity doctor, there are 35,000 patients that need care.  

What’s worse is the mindset we’ve taken regarding weight. Society tells us our weight is all about the choices we make, leading us to believe that our weight is our fault. And it’s not just the opinions of others that are factoring into this; the reality is that people that are living with overweight and obesity are stuck in a seemingly endless cycle. Many traditional weight loss programs, diet foods, and meal plans––focused on calorie counting and restrictive habits––play into the entrenched beliefs that weight loss is about willpower. Their products and services are built on outdated approaches to weight loss that may lead to short-term results, but ultimately, are unsustainable.

Sad overweight woman by the scale

That’s where Calibrate comes in. Calibrate is changing the game, including how we approach treating obesity and how members can find long-term, sustainable success with the program’s guidance.

What is Calibrate? 

Calibrate is changing how the world treats weight with a science-backed weight loss program built on decades of clinical research. Its One-Year Metabolic Reset pairs doctor-prescribed, GLP-1 medication with coaching and curriculum, alongside tracking and community to drive sustainable, long-term weight loss. Calibrate’s virtual program is built on proven methods––the latest science, prescription medication, telemedicine, and 1:1 accountability coaching on food, sleep, exercise, and emotional health. Calibrate’s earliest members lost on average 14% of their body weight in one year, exceeding clinical trial results of 10%

Calibrate developed its program based on decades of research and in partnership with an advisory board comprised of the country’s leading obesity and metabolic health experts, including the founding president of the World Obesity Federation and the Dean at the Tufts University School of Nutrition. 

Calibrate remote doctor appt.

What is the science behind Calibrate’s program?

We’ve all tried countless diets and weight loss services that rarely lead to healthy and sustainable weight loss, even if we saw some progress at the start of our weight loss journey. When we restrict calories on a diet, our system will resist weight loss in order to defend its set point. Studies show that everyone has a biological set point––the weight our body naturally settles at due to an interplay of genetics, biology, and environment. While we can’t change our genetics, we can influence our environment and how our biology responds to it. Sustainable weight loss can only be achieved by rewiring our metabolic systems to have healthy responses to food, sleep, exercise, and emotional triggers. With the right tools and goals, we can lower our set point to improve our metabolic health. 

What medications do Calibrate doctors prescribe?

Calibrate doctors prescribe members GLP-1 medications because they are the most effective medications that lead to weight loss and improved metabolic health. In the body, GLP-1s are powerful hormones made by the gut that send signals to the brain to regulate appetite and blood sugar so you can feel full longer and maximize nutrient absorption. The GLP-1 medications that Calibrate doctors prescribe work on the same receptors as your naturally occurring GLP-1 hormones that play an important role in appetite, weight management, and regulating the body’s set point. 

Calibrate doctors prescribe a variety of GLP-1s and will work with you to prescribe the most medically appropriate GLP-1 for your biology, and that is also covered by your insurance. GLP-1s prescribed include semaglutide and liraglutide, which you may know under brand names like Wegovy™ and Saxenda®. 

What lifestyle changes support weight loss in Calibrate’s program? 

When it comes to improving your metabolic health, GLP-1 medication should be used in conjunction with lifestyle changes proven to support weight loss. By combining GLP-1 medications with intensive lifestyle intervention, Calibrate’s program helps lower your set point and improve your metabolic health.

Throughout your Calibrate year, you will learn to incorporate small tweaks to the Four Pillars of Metabolic Health (food, sleep, exercise, and emotional health) that add up to impactful changes in how you eat, sleep, exercise, and feel. In your bi-weekly session, you will also track your progress in the Calibrate app to review with your 1:1 accountability coach. Here’s a bit more on their philosophy for each pillar:

  • Food: Establish a sustainable and flexible approach to nutrition that focuses on minimizing fast-digesting carbs and making healthier choices without restricting or counting calories.
  • Sleep: Develop a schedule to improve sleep quality and minimize cardiometabolic health factors with 7-9 nightly hours of restful sleep. 
  • Exercise: Prioritize 150 minutes of movement each week, making it a regular and positive part of the day, and incorporate resistance training over time to improve metabolic health. 
  • Emotional Health: Incorporate science-backed methods to reduce stress and recognize emotional triggers that influence metabolic health. 

In Search Of The "Magic Pill" Of Health |

Who is Calibrate for? 

Since Calibrate’s One-Year Metabolic Reset was designed as a doctor-guided program, there are a few eligibility requirements. Calibrate is currently available to adults between the ages of 18-64 with a BMI of 30 and above (or 27 and above with other weight-related conditions such as diabetes or high cholesterol) who aren’t pregnant, breastfeeding, dealing with cancer, or recent bariatric surgery, and who are covered by a commercial or employer health insurance plan. Learn if you’re eligible today by taking Calibrate’s eligibility quiz

How much does the program cost? 

Calibrate’s One-Year Metabolic Reset is priced at $1,620, billed once, or $135, billed monthly through Affirm. For those who instead opt for the one-time Metabolic Health Assessment with a Calibrate doctor, the cost is $249. Learn more here.

Results that speak for themselves 

Calibrate is designed to drive weight loss of at least 10%, an amount that is clinically significant and sustainable for long-term health. Calibrate’s program leads to 2-3x better outcomes than GLP-1s alone and also outperforms clinical studies.


Calibrate is more than just a diet or weight loss program––its One-Year Metabolic Reset is a doctor-guided program that will improve your metabolic health and drive sustained weight loss. If you’re interested in learning more about Calibrate, don’t hesitate to check them out today.Can-a-Metabolic-Reset-Help-You-Lose-Weight


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