Letha was born in Biloxi, Mississippi, but grew up all over the world, from Canada to Japan and all across the USA. She is a 1975 University of Southern Mississippi. Letha began running at the age of 24, when her cousin, sisters and she built a 1 mile running trail through her parents' 70 acres. Her first 50K was run in February 2000, and first 100 mile race in February 2001. She currently lives in Biloxi, where, with the help of her husband and cousin, she built a 3.5 mile running trail through the woods on what is now her half of her parents' property. The running trail was completed in 2011, before the accident that left her husband a quadriplegic. Her 100 mile personal record is 20:29:04, and she has finished 34 races of 100 miles or longer, with her longest distance being 138.9 miles. Letha has been married for 40 years and has one daughter. She will be 64 in August 2017.