Is Sodium Deoxycholate REALLY Similar To Botox? | Prime Women

Is This Topical Ingredient REALLY Similar To Botox?

sodium deoxycholate

It seems like every day we’re hearing out the latest anti-aging ingredient in skincare. But when we hear about a topical ingredient that’s been compared to Botox, we have to stop and listen. If you’re a fan of Korean beauty products, you’ve probably already heard about sodium deoxycholate. But just in case you haven’t, anything with this ingredient may be worth trying. Keep reading to learn more about sodium deoxycholate, how it works, and why it may just be the topical equivalent of Botox.  

What is sodium deoxycholate?

Sodium deoxycholate is a salt that acts as a solubilizer and detergent that lyses certain cells. It’s been successfully used as an injectable to break down fat cells. Scientists are currently in the process of determining its efficiency as a skin-penetrating topical ingredient. That hasn’t stopped skincare companies from rolling out their own sodium deoxycholate products, though. 

How does it work? 

Sodium deoxycholate basically functions to break down fat cells. It’s used as an injectable to induce lipolysis and redistribute subcutaneous fat (fat that’s right underneath the skin) to reshape parts of the face (like eye bags or nasolabial folds). As an injectable, it carries a 93.5% success rate). And in theory, people can apply this ingredient topically to the skin to reduce lipolysis (breaking down fat cells). Scientists are in the process of determining exactly how well it performs topically. 

Sodium Deoxycholate and Side Effects

Like many other skincare ingredients, the side effects will depend on the product’s concentration. So far, the biggest potential risks are skin irritation and inflammation. It’s always a good rule of thumb to apply a patch test to a small area of your skin to be sure. However, The jury is still out on the concentration threshold for this ingredient, so if you have a history of sensitive skin, eczema, or other skin allergies, you may want to avoid it until more information is available. 

Is this ingredient safe to pair with other ingredients?

Because this ingredient is all about its penetrating abilities, it may be wise to avoid pairing it with other skin-penetrating enhancers, like butylene glycol, ethoxydiglycol, and propylene glycol. It’s possible that using all of these ingredients at once may irritate the skin. 

However, if you have sensitive skin, it’s always wise to do a patch test before applying it to your entire face. 

How to Use This Ingredient Topically

If you decide to try this topical ingredient for yourself, it’s best to apply it to freshly cleansed skin. Because the ingredient relies on its ability to penetrate the skin, it may be best to apply it to freshly exfoliated skin, as the dead skin cells have just been washed away. However, don’t combine it with retinoids or acids — you may end up with irritated skin. 

Products With Sodium Deoxycholate

If you’re curious to try this ingredient topically, there are a couple of products out there that you may want to try: 

Hyaluid 100ml, $84

Hyaluid 100ml

If you’re shopping for products that contain sodium deoxycholate, you’ve probably seen this product front and center. Hyaluid floods skin with eight different weights of Hyaluronic Acid and multiple forms of saccharides (carbohydrates) that deposit at shallow to deeper layers of skin accordingly. It works to refill empty spaces of the extra-cellular matrix (structural network) that is naturally declining in Glycosaminoglycans due to natural aging and sun exposure. Together, they swell up into rich hydration balloons by the natural attraction of water and ions, resulting in visibly plumper skin externally. 

Private Doctor Define Minus Serum, $49


This silky, skin-smoothing anti-aging serum is inspired by ID Hospital’s in-office treatments. It targets sagging skin, wrinkles, and areas that lack elasticity, including the neck and decollete.
This formula is also infused with ID.SCULPT Technology — a blend of Micro-Tingling Spicules and a patented Sodium Deoxycholate Complex — that work together to help define and firm the appearance of skin over time.

The Takeaway

While this ingredient certainly works well as an injectable, it’s still unclear whether or not it can effectively penetrate the skin when applied topically. More research is needed before placing your hopes on a topical product that may outperform an injectable. However, if you’d like to try it in injectable form, look into FDA-approved Kybella (deoxycholic acid). If you’re interested in trying this buzzy injectable, be sure and check out Ageless Beauty, our database of reader-selected doctors in your area. We’ve rounded up the best plastic surgeons, cosmetic dentists, dermatologists, and thanatologists in your area.

Related Article: As we get older, the number of natural proteins in our skin decreases. Our elastin and collagen levels lessen, which can lead to sagging, wrinkles, and overall dryness. Another key compound our skin starts to produce less of through the years is hyaluronic acid. This powerful substance aids skin in reparation and hydration. Read more about hyaluronic acid and the best products to try today.

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